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Low muscle tone Flat facial features, with a small nose.

Upward slant to the eyes

Small skin folds on the inner corner of the eyes

Small, abnormally shaped ears

Single deep crease across the centre of the palm

Hyperflexibility (excessive ability to flex joints)

Fifth finger has only one flexion furrow instead of two

Extra space between the big toe and the second toe

Enlarged tongue that tends to stick out